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There can be many disorders related to the central nervous system associated with the brain. Diseases such as psychiatric disorders, neurodegeneration, chronic pain, brain tumors, etc. are associated with this. Even stroke is a disorder of the central nervous system. Doctors believe that peptide pharmaceuticals are the only ones that provide benefits for these disorders. A recent study suggests that spraying medication into the nose may help cure a stroke (effect of nasal spray on stroke).
What the Study Is About (Effect of Nasal Spray on Brain Study)
Researchers from the Swiss Federal Institute of Technology and the University of Newcastle in Zurich conducted this study on rats affected by a stroke. The team first cut off blood flow to parts of the mice’s brains. He then examined the effects of stroke. Some mice were given an antibody nasal spray once a day for two weeks.
Dealing with the effects of a stroke
They were found to improve by 60 percent four weeks after the stroke. While in rats taking a placebo treatment, this figure was around 30 percent. According to the researchers, a medication that can be sprayed into the nose can counteract the effects of stroke. They can be sprayed over the nose and delivered to the brain.
Therapeutic peptides present in the nasal spray
The nasal spray is in the form of a spray. Contains therapeutic peptide compounds. Its delivery is possible from the nose to the brain.
The team of researchers examined the brains of rats. They found that more new nerve fibers were seen in the treated mice. Here, the antibody level is effective in repairing the wound caused by stroke. This shows that there is regenerative power within the brain.
Antibody molecules sprayed into the noses of the mice repaired brain damage similar to that of a stroke. This may be because the drugs travel through nerve cells.
The journey of drugs to the nerve cell
According to previous studies, some drugs travel to nerve cells that detect odors. It may be able to reach the brain through the nose. Because they contain long fibers, which extend from the nostrils to the brain. Medicines that counteract the effects of a stroke can be sprayed up the nose and delivered into the brain.
The delivery of large drug molecules to the brain has long been a major medical challenge. Most compounds cannot reach the brain in large amounts. Because the walls of the vessels that carry pure blood to the brain are very impenetrable. which is known as the blood-brain barrier.
How did the antibody journey happen?
The researchers tested the antibodies produced from a nasal spray. It blocks a compound called Nogo-A in the brain. It normally stops the growth of brain cells.
The study did not test how the antibodies traveled through the nerves to reach the brain. Because they could be absorbed into the bloodstream from the nose. Very small amounts of these could reach the brain.
Effect on memory
Previous research suggests that when the nasal spray is sprayed into the nose. So insulin could potentially help improve memory. It may help maintain cognitive function in people with early-onset Alzheimer’s disease or mild cognitive impairment. However, the study results do not fully support this. Some later tests showed negative results for the effect of the nasal spray on memory.
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